Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study
Abstract Background Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD).Serological neoepitope markers of collagen turnover may predict rate of change in FEV1.Methods One thousand COPD subjects from the observational, multicentre, three-year ECLIPSE (Evaluation o